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MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H+ Transporting V1 Subunit C1

Authors
  • Jing, Fei
  • Geng, Yan
  • Xu, Xin-Yi
  • Xu, Hong-Yu
  • Shi, Jin-Song
  • Xu, Zheng-Hong
Publication Date
Feb 13, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

-SMA) and increased lipid-related genes expression. Simultaneous addition of MIR29a mimics and ATP6V1C1 siRNA further increased RSG promoted expression of lipid-related proteins in vitro. Collectively, MIR29a plays an important role during the trans-differentiation of aHSCs in the resolution of liver fibrosis, in part, through regulation of ATP6V1C1.

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