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The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma.

Authors
  • Guo, Xiaofang
  • Liao, Qianjin
  • Chen, Pan
  • Li, Xiayu
  • Xiong, Wei
  • Ma, Jian
  • Li, Xiaoling
  • Luo, Zhaohui
  • Tang, Hailin
  • Deng, Min
  • Zheng, Yin
  • Wang, Rong
  • Zhang, Wenling
  • Li, Guiyuan
Type
Published Article
Journal
Journal of Cancer Research and Clinical Oncology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2012
Volume
138
Issue
1
Pages
49–56
Identifiers
DOI: 10.1007/s00432-011-1058-1
PMID: 21953080
Source
Medline
License
Unknown

Abstract

We observed that Drosha and Dicer expression was dysregulation in NPC compared with healthy control samples and was significantly correlated with shorter PFS and OS of NPC patients. Therefore, we hypothesise that the expression levels of Dicer and Drosha could be used as potential prognostic biomarkers for NPC.

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