Affordable Access

deepdyve-link
Publisher Website

MicroRNA: a novel implication for damage and protection against ionizing radiation

Authors
  • Chen, Yonglin1, 2
  • Cui, Jian1, 2
  • Gong, Yaqi1, 2
  • Wei, Shuang1, 2
  • Wei, Yuanyun1, 2
  • Yi, Lan1, 2
  • 1 University of South China,
  • 2 Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001 Hunan Province People’s Republic of China
Type
Published Article
Journal
Environmental Science and Pollution Research
Publisher
Springer-Verlag
Publication Date
Feb 03, 2021
Pages
1–13
Identifiers
DOI: 10.1007/s11356-021-12509-5
PMID: 33533004
PMCID: PMC7854028
Source
PubMed Central
Keywords
License
Unknown

Abstract

Ionizing radiation (IR) is a form of high energy. It poses a serious threat to organisms, but radiotherapy is a key therapeutic strategy for various cancers. It is significant to reduce radiation injury but maximize the effect of radiotherapy. MicroRNAs (miRNAs) are posttranscriptionally regulatory factors involved in cellular radioresponse. In this review, we show how miRNAs regulate important genes on cellular response to IR-induced damage and how miRNAs participate in IR-induced carcinogenesis. Additionally, we summarize the experimental and clinical evidence for miRNA involvement in radiotherapy and discuss their potential for improvement of radiotherapy. Finally, we highlight the role that miRNAs play in accident exposure to IR or radiotherapy as predictive biomarker. miRNA therapeutics have shown great perspective in radiobiology; miRNA may become a novel strategy for damage and protection against IR.

Report this publication

Statistics

Seen <100 times