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MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis.

Authors
  • Qin, Bing1
  • Xiao, Bo
  • Liang, Desheng
  • Li, Ye
  • Jiang, Ting
  • Yang, Huan
  • 1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China. , (China)
Type
Published Article
Journal
BMB reports
Publication Date
Aug 01, 2012
Volume
45
Issue
8
Pages
464–469
Identifiers
DOI: 10.5483/BMBRep.2012.45.8.033
PMID: 22917031
Source
Medline
License
Unknown

Abstract

Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. MiRNA let-7 family is known to be involved in the regulation of cell apoptosis. However, the function of let-7 in ox-LDL induced ECs apoptosis and atherosclerosis is still unknown. Here, we show that let-7c expression was markedly up-regulated in ox-LDL induced apoptotic human umbilical cord vein endothelial cells (HUVECs). Let-7c over-expression enhanced apoptosis in ECs whereas inhibition of let-7c could partly alleviate apoptotic cell death mediated by ox-LDL. Searching for how let-7c affected apoptosis, we discovered that antiapoptotic protein Bcl-xl was a direct target of let-7c in ECs. Our data suggest that let-7c contributes to endothelial apoptosis through suppression of Bcl-xl.

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