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MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition.

Authors
  • Zhou, Yun1
  • Li, Yuan
  • Ye, Jing
  • Jiang, Rongrong
  • Yan, Han
  • Yang, Xiaojun
  • Liu, Qizhan
  • Zhang, Jianping
  • 1 Department of General Surgery, The Second Affiliated Hospital, School of Public Health, Nanjing Medical University, Nanjing, China. , (China)
Type
Published Article
Journal
Liver international : official journal of the International Association for the Study of the Liver
Publication Date
Sep 01, 2013
Volume
33
Issue
8
Pages
1271–1280
Identifiers
DOI: 10.1111/liv.12190
PMID: 23725476
Source
Medline
Keywords
License
Unknown

Abstract

Our results suggest that miR-491 is involved in metastasis of HCC by blocking EMT and decreasing MMP-9 levels, which may provide a new clue for preventing tumour metastasis of HCC.

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