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microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells.

Authors
  • Zhou, Chang1
  • Li, Xiaofeng
  • Zhang, Xiaoting
  • Liu, Xizhi
  • Tan, Zhiwen
  • Yang, Celi
  • Zhang, Jian
  • 1 Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China. [email protected] , (China)
Type
Published Article
Journal
International Journal of Oncology
Publisher
Spandidos Publications
Publication Date
Feb 01, 2013
Volume
42
Issue
2
Pages
635–642
Identifiers
DOI: 10.3892/ijo.2012.1737
PMID: 23242208
Source
Medline
License
Unknown

Abstract

Aberrant microRNA (miRNA) expression has been investigated in gastric cancer, which is one of the most common malignancies. However, the roles of miRNAs in gastric cancer remain largely unknown. In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, α-induced protein 1 (TNFAIP1), and is involved in the regulation of the NFκB signaling pathway. Furthermore, overexpression of TNFAIP1 induced changes in AGS cells similar to those in AGS cells treated with miR-372-ASO. Collectively, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth and apoptosis through downregulation of TNFAIP1. This novel molecular basis provides new insights into the etiology of gastric cancer.

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