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microRNA-24a is required to repress apoptosis in the developing neural retina.

Authors
  • Walker, James C
  • Harland, Richard M
Type
Published Article
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Publication Date
May 01, 2009
Volume
23
Issue
9
Pages
1046–1051
Identifiers
DOI: 10.1101/gad.1777709
PMID: 19372388
Source
Medline
License
Unknown

Abstract

Programmed cell death is important for the proper development of the retina, and microRNAs (miRNAs) may be critical for its regulation. Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus. Inhibition of miR-24a during development causes a reduction in eye size due to a significant increase in apoptosis in the retina, whereas overexpression of miR-24a is sufficient to prevent apoptosis. We show that miR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development.

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