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microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells.

Authors
  • Satzger, Imke
  • Mattern, Anika
  • Kuettler, Uta
  • Weinspach, Dirk
  • Niebuhr, Margarete
  • Kapp, Alexander
  • Gutzmer, Ralf
Type
Published Article
Journal
Experimental Dermatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2012
Volume
21
Issue
7
Pages
509–514
Identifiers
DOI: 10.1111/j.1600-0625.2012.01510.x
PMID: 22716245
Source
Medline
License
Unknown

Abstract

Overexpression of microRNA-21 (miR-21) has been observed in various cancer types, but little is known about the role of miR-21 in melanoma. In this study, we demonstrate that levels of miR-21 are significantly increased in primary melanoma tissues as compared to benign nevi and in human melanoma cell lines as compared to melanocytic cell preparations. We show that downregulation of miR-21 in melanoma cell lines with high endogenous miR-21 expression induced apoptosis, whereas proliferation was not significantly altered. Upregulation of miR-21 in melanocytes resulted in increased proliferation and decreased apoptosis. However, in the MEWO melanoma cells with low endogenous miR-21 expression, upregulation of miR-21 had no functional effects. These findings indicate a potential pathogenetic role of miR-21 upregulation in a subgroup of melanomas.

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