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MicroRNA-21 in breast cancer: diagnostic and prognostic potential

Authors
  • Chen, J.1
  • Wang, X.1
  • 1 Zhejiang Cancer Hospital, Department of Medical Oncology (Breast), 38 Guangji Road, Hangzhou, Zhejiang, 310022, China , Hangzhou (China)
Type
Published Article
Journal
Clinical & Translational Oncology
Publisher
Springer-Verlag
Publication Date
Nov 19, 2013
Volume
16
Issue
3
Pages
225–233
Identifiers
DOI: 10.1007/s12094-013-1132-z
Source
Springer Nature
Keywords
License
Yellow

Abstract

Breast cancer is the most common malignancy in women and is considered as a complex and heterogeneous disease. The identification of novel biomarkers for early detection of breast cancer and prediction of disease outcome is urgently required. MicroRNAs (miRNAs) are small non-coding endogenous RNA molecules that act to regulate gene expression and play vital roles in many crucial processes. Recent evidence demonstrates that miRNAs could emerge as revolutionary sources of biomarkers for cancer diagnosis and prognosis. miR-21 is one of the most commonly observed aberrant miRNAs in a variety of cancers including breast cancer. Emerging studies show that miR-21 could be measured stably and easily in tumor tissues, formalin-fixed paraffin-embedded tissues and blood circulation. In this review, we will summarize the current evidence of miR-21 as a promising biomarker for diagnosis and prognosis in breast cancer. We will also discuss the issues and challenges of miR-21 as a potential biomarker in future clinical applications.

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