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Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women

Authors
  • Schiuma, N.1
  • Costantino, A.1
  • Bartolotti, T.1
  • Dattilo, M.2
  • Bini, V.3
  • Aglietti, M. C.3
  • Renga, M.3
  • Favilli, A.3
  • Falorni, A.3
  • Gerli, S.3
  • 1 Centro Demetra ARTeBIOS, Via Giardini 11, Lugo, RA Italy
  • 2 Parthenogen, Piazza Indipendenza 11, Lugano, Switzerland
  • 3 University of Perugia,
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Dec 16, 2019
Volume
43
Issue
6
Pages
779–786
Identifiers
DOI: 10.1007/s40618-019-01163-x
PMID: 31845191
PMCID: PMC7230049
Source
PubMed Central
Keywords
License
Unknown

Abstract

Purpose Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. Methods This was a prospective, randomized, parallel group, open label, controlled versus no treatment clinical study. PCOS women aged > 18, free from systemic diseases and from pharmacological treatments were randomized with a 2:1 ratio for treatment with activated micronutrients in support to the carbon cycle (Impryl, Parthenogen, Switzerland— n = 22) or no treatment ( n = 10) and followed-up for 3 months. Fasting blood homocysteine, AMH, testosterone, SHBGs, and the resulting FTI were tested before and at the end of the follow-up. Results The mean baseline fasting blood homocysteine was above the normal limit of 12 μMol/L and inversely correlated with SHBG. AMH was also increased, whereas testosterone, SHBG, and FTI were within the normal limit. The treatment achieved a significant reduction of homocysteine, that did not change in the control group, independently of the starting value. The treatment also caused an increase of AMH and a decrease of SHBGs only in the subgroup with a normal homocysteine at baseline. Conclusions In PCOS ladies, blood homocysteine is increased and inversely correlated with the SHBGs. Physiologic amounts of activated micronutrients in support to the carbon cycle achieve a reduction virtually in all exposed patients. Whether this is of clinical benefit remains to be established.

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