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Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women.

Authors
  • Schiuma, N1
  • Costantino, A1
  • Bartolotti, T1
  • Dattilo, M2
  • Bini, V3
  • Aglietti, M C3
  • Renga, M3
  • Favilli, A4
  • Falorni, A3
  • Gerli, S4
  • 1 Centro Demetra ARTeBIOS, Via Giardini 11, Lugo, RA, Italy. , (Italy)
  • 2 Parthenogen, Piazza Indipendenza 11, Lugano, Switzerland. [email protected] , (Switzerland)
  • 3 Section of Internal Medicine and Endocrine and Metabolic Sciences, Department of Medicine, University of Perugia, Perugia, Italy. , (Italy)
  • 4 Section of Obstetrics and Gynecology, Department of Surgical and Biomedical Sciences, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. , (Italy)
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Jun 01, 2020
Volume
43
Issue
6
Pages
779–786
Identifiers
DOI: 10.1007/s40618-019-01163-x
PMID: 31845191
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. This was a prospective, randomized, parallel group, open label, controlled versus no treatment clinical study. PCOS women aged > 18, free from systemic diseases and from pharmacological treatments were randomized with a 2:1 ratio for treatment with activated micronutrients in support to the carbon cycle (Impryl, Parthenogen, Switzerland-n = 22) or no treatment (n = 10) and followed-up for 3 months. Fasting blood homocysteine, AMH, testosterone, SHBGs, and the resulting FTI were tested before and at the end of the follow-up. The mean baseline fasting blood homocysteine was above the normal limit of 12 μMol/L and inversely correlated with SHBG. AMH was also increased, whereas testosterone, SHBG, and FTI were within the normal limit. The treatment achieved a significant reduction of homocysteine, that did not change in the control group, independently of the starting value. The treatment also caused an increase of AMH and a decrease of SHBGs only in the subgroup with a normal homocysteine at baseline. In PCOS ladies, blood homocysteine is increased and inversely correlated with the SHBGs. Physiologic amounts of activated micronutrients in support to the carbon cycle achieve a reduction virtually in all exposed patients. Whether this is of clinical benefit remains to be established.

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