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Micronucleus Assay: The State of Art, and Future Directions

Authors
  • Sommer, Sylwester1
  • Buraczewska, Iwona1
  • Kruszewski, Marcin1, 2
  • 1 (M.K.)
  • 2 Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Feb 24, 2020
Volume
21
Issue
4
Identifiers
DOI: 10.3390/ijms21041534
PMID: 32102335
PMCID: PMC7073234
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage. In this minireview, we focus on the position of MN among the other genotoxicity tests, its usefulness in different applications and visibility by international organizations, such as International Atomic Energy Agency, Organization for Economic Co-operation and Development and International Organization for Standardization. In addition, the mechanism of micronuclei formation is discussed. Finally, foreseen directions of the MN development are pointed, such as automation, buccal cells MN and chromothripsis phenomenon.

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