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Microneedles in Smart Drug Delivery.

Authors
  • Bilal, Muhammad1, 2
  • Mehmood, Shahid3
  • Raza, Ali4
  • Hayat, Uzma4
  • Rasheed, Tahir5
  • Iqbal, Hafiz M N6
  • 1 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • 2 Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • 3 Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. , (China)
  • 4 School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. , (China)
  • 5 School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China. , (China)
  • 6 Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico. , (Mexico)
Type
Published Article
Journal
Advances in wound care
Publication Date
Apr 01, 2021
Volume
10
Issue
4
Pages
204–219
Identifiers
DOI: 10.1089/wound.2019.1122
PMID: 32320365
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Significance: In biomedical setup, at large, and drug delivery, in particular, transdermal patches, hypodermal needles, and/or dermatological creams with the topical appliance are among the most widely practiced routes for transdermal drug delivery. Owing to the stratum corneum layer of the skin, traditional drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. Recent Advances: The current advancement at the microlevel and nanolevel has revolutionized the drug delivery sector. Particularly, various types of microneedles (MNs) are becoming popular for drug delivery applications because of safety, patient compliance, and smart action. Critical Issues: Herein, we reviewed state-of-the-art MNs as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of MNs is discussed. Different types of MNs, that is, solid, hollow, coated, dissolving, and hydrogel forming, are discussed with suitable examples. The latter half of the work is focused on the applied perspective and clinical translation of MNs. Furthermore, a detailed overview of clinical applications and future perspectives is also included in this review. Future Directions: Regardless of ongoing technological and clinical advancement, the focus should be diverted to enhance the efficacy and strength of MNs. Besides, the possible immune response or interference should also be avoided for successful clinical translation of MNs as an efficient drug delivery system.

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