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Microimplantation of foreign materials for assessment of foreign body immune responses and granuloma formation in zebrafish larvae

Authors
  • Takaki, Kevin K.1
  • 1 Molecular Immunity Unit, MRC Laboratory of Molecular Biology and Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge, UK
Type
Published Article
Journal
STAR Protocols
Publisher
Elsevier
Publication Date
Sep 15, 2021
Volume
2
Issue
4
Identifiers
DOI: 10.1016/j.xpro.2021.100835
PMID: 34568848
PMCID: PMC8449182
Source
PubMed Central
Keywords
Disciplines
  • Protocol
License
Unknown

Abstract

This protocol describes the microimplantation of foreign materials such as schistosome eggs, polymer beads, and other microscopic objects into the small and optically transparent larval zebrafish for the assessment of immune responses, including granuloma formation. This protocol has wide applicability for both fundamental studies on host responses to parasite eggs and other foreign bodies, as well as the testing of potential biomaterials and devices used for human medical implants.

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