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Microglial phagocytosis of dopamine neurons at early phases of apoptosis.

Authors
  • Cho, Byung Pil
  • Sugama, Shuei
  • Shin, Dong Hoon
  • DeGiorgio, Lorraine A
  • Kim, Sung Soo
  • Kim, Yoon Seong
  • Lim, So Young
  • Park, Key Chung
  • Volpe, Bruce T
  • Cho, Sunghee
  • Joh, Tong H
Type
Published Article
Journal
Cellular and molecular neurobiology
Publication Date
Oct 01, 2003
Volume
23
Issue
4-5
Pages
551–560
Identifiers
PMID: 14514015
Source
Medline
License
Unknown

Abstract

Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and OX-6 (MHC-II marker)-positive and ED1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. The occurrence of microglial phagocytosis at early stages of apoptosis may indicate the evolution of apoptosis into an irreversible state. Alternatively, interventions that suppress early activation of microglia might lead to novel mechanisms for neuron protection.

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