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Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition

Authors
  • Croisier, Emilie1
  • Moran, Linda B1
  • Dexter, David T2
  • Pearce, Ronald KB1
  • Graeber, Manuel B1
  • 1 Imperial College London, and Hammersmith Hospitals Trust, Department of Neuropathology, Division of Neuroscience and Mental Health, London, UK , London
  • 2 Imperial College London, Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, London, UK , London
Type
Published Article
Journal
Journal of Neuroinflammation
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 03, 2005
Volume
2
Issue
1
Identifiers
DOI: 10.1186/1742-2094-2-14
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundThe role of both microglial activation and alpha-synuclein deposition in Parkinson's disease remain unclear. We have tested the hypothesis that if microglia play a primary role in Parkinson's disease pathogenesis, the microglial "activated" phenotype should be associated with histopathological and/or clinical features of the disease.MethodsWe have examined microglial MHC class II expression, a widely used marker of microglial activation, the occurrence of CD68-positive phagocytes and alpha-synuclein immunoreactivity in post-mortem human substantia nigra affected by idiopathic Parkinson's disease (PD). Using semi-quantitative severity ratings, we have examined the relationship between microglial activation, alpha-synuclein deposition, classical neuropathological criteria for PD, subtype of the disease and clinical course.ResultsWhile we did not observe an association between microglial MHC class II expression and clinical parameters, we did find a correlation between disease duration and the macrophage marker CD68 which is expressed by phagocytic microglia. In addition, we observed a significant correlation between the degree of MHC class II expression and alpha-synuclein deposition in the substantia nigra in PD.ConclusionWhile microglia appeared to respond to alpha-synuclein deposition, MHC class II antigen expression by microglia in the substantia nigra cannot be used as an indicator of clinical PD severity or disease progression. In addition, a contributory or even causative role for microglia in the neuronal loss associated with PD as suggested by some authors seems unlikely. Our data further suggest that an assessment of microglial activation in the aged brain on the basis of immunohistochemistry for MHC class II antigens alone should be done with caution.

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