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Microglial APOE4: more is less and less is more.

Authors
  • Eskandari-Sedighi, Ghazaleh
  • Blurton-Jones, Mathew
Publication Date
Dec 19, 2023
Source
eScholarship - University of California
Keywords
License
Unknown
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Abstract

Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimers disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have employed complementary gain-of-function and loss-of-function approaches to provide critical new insight into the impact of microglial APOE on AD pathogenesis.

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