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Microglial Activation and Neuroinflammation in Alzheimer's Disease: A Critical Examination of Recent History

Authors
  • Streit, Wolfgang J.1
  • 1 Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, USA
Type
Published Article
Journal
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Publication Date
Jun 03, 2010
Volume
2
Identifiers
DOI: 10.3389/fnagi.2010.00022
Source
Frontiers
Keywords
Disciplines
  • Neuroscience
  • Perspective Article
License
Green

Abstract

The neurofibrillary degeneration that occurs in Alzheimer's disease (AD) is thought to be the result of a chronic and damaging neuroinflammatory response mediated by neurotoxic substances produced by activated microglial cells. This neuroinflammation hypothesis of AD pathogenesis has led to numerous clinical trials with anti-inflammatory drugs, none of which have shown clear benefits for slowing or preventing disease onset and progression. In this paper, I make the point that AD is not an inflammatory condition, and reconstruct the sequence of events during the 1980s and 1990s that I believe led to the development of this faulty theory.

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