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Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

Authors
  • Hasani-Sadrabadi, Mohammad Mahdi
  • Taranejoo, Shahrouz
  • Dashtimoghadam, Erfan
  • Bahlakeh, Ghasem
  • Majedi, Fatemeh Sadat
  • Vandersarl, Jules John
  • Janmaleki, Mohsen
  • Sharifi, Fatemeh
  • Bertsch, Arnaud
  • Hourigan, Kerry
  • Tayebi, Lobat
  • Renaud, Philippe
  • Jacob, Karl I.
Publication Date
Jan 01, 2016
Source
Infoscience @ EPFL
Keywords
License
Unknown
External links

Abstract

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

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