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A microfluidic-based frequency-multiplexing impedance sensor (FMIS).

Authors
  • Meissner, Robert1
  • Joris, Pierre
  • Eker, Bilge
  • Bertsch, Arnaud
  • Renaud, Philippe
  • 1 Laboratoire de Microsystèmes LMIS4, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. [email protected] , (Switzerland)
Type
Published Article
Journal
Lab on a Chip
Publisher
The Royal Society of Chemistry
Publication Date
Aug 07, 2012
Volume
12
Issue
15
Pages
2712–2718
Identifiers
DOI: 10.1039/c2lc40236j
PMID: 22627460
Source
Medline
License
Unknown

Abstract

We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each 'sub-sensor' possesses its corresponding measurement frequency where the sample-specific dielectric properties can be probed. We have shown the validity of our frequency-multiplexing impedance sensor (FMIS) by comparison with conventional 'single sensors'. Our highly sensitive FMIS was proven suitable for life science applications through usage as a cell-based toxicology platform. We are confident that our technology might find great utility in parallelized cell-based analysis systems as well as in biomedical devices where size limitations and spatially distributed probing are important parameters.

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