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Microfabricated high-throughput electronic particle detector.

Authors
  • Wood, D K
  • Requa, M V
  • Cleland, A N
Type
Published Article
Journal
The Review of scientific instruments
Publication Date
Oct 01, 2007
Volume
78
Issue
10
Pages
104301–104301
Identifiers
PMID: 17979441
Source
Medline
License
Unknown

Abstract

We describe the design, fabrication, and use of a radio frequency reflectometer integrated with a microfluidic system, applied to the very high-throughput measurement of micron-scale particles, passing in a microfluidic channel through the sensor region. The device operates as a microfabricated Coulter counter [U.S. Patent No. 2656508 (1953)], similar to a design we have described previously, but here with significantly improved electrode geometry as well as including electronic tuning of the reflectometer; the two improvements yielding an improvement by more than a factor of 10 in the signal to noise and in the diametric discrimination of single particles. We demonstrate the high-throughput discrimination of polystyrene beads with diameters in the 4-10 microm range, achieving diametric resolutions comparable to the intrinsic spread of diameters in the bead distribution, at rates in excess of 15 x 10(6) beads/h.

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