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Microencapsulated mammalian cells for simultaneous production of VEGF165b and IFNα.

Authors
  • Afkhami, Fatemeh
  • Durocher, Yves
  • Prakash, Satya
Type
Published Article
Journal
Artificial cells, blood substitutes, and immobilization biotechnology
Publication Date
Feb 01, 2012
Volume
40
Issue
1-2
Pages
1–6
Identifiers
DOI: 10.3109/10731199.2011.560120
PMID: 22288840
Source
Medline
License
Unknown

Abstract

Targeted and simultaneous delivery VEGF165b and IFN alpha in anti-angiogenic and other applications could offer several advantages. For this a system was design using artificial cell alginate-poly-L-lysine- alginate (APA) microcapsules. Result confirms the ability of this system for simultaneous production of these proteins for 28-days. The IFN alpha on a 3 days period increased from 8 ± 0.36 μg/ml at day 10 to 27 ± 2.4 μg/ml at day 16 and then dropped to 6.5 ± 0.5 μg/ml. The VEGF165b on a 3 days period increased from 2.7 ± 0.7 μg/ml at day 10 to 6.9 ± 1 μg/ml at day 16.

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