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Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.

Authors
  • Ichinose, M
  • Endo, S
  • Critz, S D
  • Shenolikar, S
  • Byrne, J H
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Nov 12, 1990
Volume
533
Issue
1
Pages
137–140
Identifiers
PMID: 1964827
Source
Medline
License
Unknown

Abstract

Microcystin-LR (MCYST-LR), a hepatotoxin produced by cyanobacteria, inhibited purified protein phosphatases (PrPs) from rabbit skeletal muscle and the enzymes from Aplysia with an IC50 of approximately 10(-10) M. MCYST-LR also prolonged both serotonin- (5-HT) and cyclic adenosine monophosphate-induced inward currents in sensory neurons of Aplysia. These results, which are consistent with inhibition of Aplysia PrPs, indicate that MCYST-LR may be a useful probe to elucidate the function of PrPs in neural tissues.

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