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Microcystic adnexal carcinoma-diagnostic criteria and therapeutic methods: case report and review of the literature.

Authors
  • Mamic, M1
  • Manojlovic, L2
  • Suton, P3
  • Luksic, I4
  • 1 Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia. , (Croatia)
  • 2 Department of Pathology, University Hospital Dubrava, Zagreb, Croatia. , (Croatia)
  • 3 Division of Radiation Oncology, Department of Radiotherapy and Medical Oncology, University Hospital for Tumours, University Hospital Centre "Sisters of Mercy", Zagreb, Croatia. , (Croatia)
  • 4 Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia. Electronic address: [email protected] , (Croatia)
Type
Published Article
Journal
International journal of oral and maxillofacial surgery
Publication Date
Oct 01, 2018
Volume
47
Issue
10
Pages
1258–1262
Identifiers
DOI: 10.1016/j.ijom.2018.03.001
PMID: 29602625
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Microcystic adnexal carcinoma (MAC) is a rare, infiltrating, locally aggressive cutaneous neoplasm of combined follicular and eccrine/apocrine histogenesis, usually presenting on the upper lip or face. Differentiation from other adnexal tumours is very important because the clinical management of these tumours is radically different, and misdiagnosis may lead to incorrect treatment. A case of recurrent MAC in the upper lip, treated with multiple excisions and postoperative radiation therapy (PORT), is presented herein. There have been no signs or symptoms of recurrence since the subsequent reconstructive surgery and PORT. Based on reports in the literature it appears that although immunohistochemistry can be helpful in distinguishing between MAC and other adnexal tumours, careful histopathological examination is essential for an accurate diagnosis. Perineural and intramuscular invasion strongly suggest the diagnosis of MAC. Its predilection for the facial area often limits the width of surgical excision. In such cases, PORT may be considered. Copyright © 2018. Published by Elsevier Ltd.

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