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Microcirculation and tissue metabolism in peripheral arterial disease.

Authors
  • Brevetti, G
  • Corrado, S
  • Martone, V D
  • Di Donato, A
  • Silvestro, A
  • Vanni, L
Type
Published Article
Journal
Clinical hemorheology and microcirculation
Publication Date
Jan 01, 1999
Volume
21
Issue
3-4
Pages
245–254
Identifiers
PMID: 10711750
Source
Medline
License
Unknown

Abstract

It is now clear that different pathophysiologic mechanisms have a profound influence on the extent of the functional impairment in intermittent claudication. In particular, metabolic derangements, including impaired oxygen delivery and/or extraction, reduced nitric oxide synthesis, reduced glucose oxidation, accumulation of toxic metabolites and reduction in carnitine availability are correlated with disease severity. Therefore, metabolic interventions aimed at counteracting these alterations may represent a valid therapeutic approach to the treatment of this condition. To date, verapamil and L-arginine efficacy has been proven in few patients; a large scale clinical trial, conversely, reports that propionyl-L-carnitine appears to be an effective and well tolerated drug for the treatment of intermittent claudication.

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