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Microcapsules responsive to pH and temperature: synthesis, encapsulation and release study

Authors
  • Pentela, Nagaraju1, 2
  • Rainu, Simran1
  • Duraipandy, N.2, 3
  • Boopathi, A. A.1, 2
  • Kiran, M. S.3
  • Sampath, Srinivasan4
  • Samanta, Debasis1, 2
  • 1 Council of Scientific and Industrial Research (CSIR)-CLRI, Polymer Science and Technology Department, Adyar, Chennai, 600020, India , Adyar, Chennai (India)
  • 2 Academy of Scientific and Innovative Research, Rafi Marg, New Delhi, India , Rafi Marg, New Delhi (India)
  • 3 CSIR-CLRI, Biological Material Laboratory, Chennai, 600020, India , Chennai (India)
  • 4 Central University of Tamil Nadu, Department of Materials Science, School of Technology, Thiruvarur, 610101, India , Thiruvarur (India)
Type
Published Article
Journal
SN Applied Sciences
Publisher
Springer International Publishing
Publication Date
Apr 11, 2019
Volume
1
Issue
5
Identifiers
DOI: 10.1007/s42452-019-0371-1
Source
Springer Nature
Keywords
License
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Abstract

In this present article, we report preparation of dual responsive microcapsules by using poly(N-isopropyl acrylamide-co-methacrylic acid) [poly(NIPAM-co-MAA)] and acid functionalized graphene oxide (GO). While the methacrylic acid part is responsible for the responsiveness towards the change in pH, N-isopropylacrylamide part is responsible for the responsiveness towards change in temperatures. Functionalized GO forms the core of the microcapsules and its interaction with the polymer controls the movement of the encapsulated materials in response to change in neighboring environment. Surface morphology and interconnectivity of the microcapsules was observed by optical polarized microscopy and the presence of the GO sheets on the wall was observed in High Resolution Transmission Electron Microscopy images. The pH and temperature responsive nature of the microcapsules were studied by loading vitamin B2 or anticancer drug cisplatin. It was found that both pH and temperature influences releasing pattern of the either drug from microcapsule.

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