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Microbiota reprogramming for treatment of alcohol-related liver disease.

Authors
  • Siddiqui, Mohamed Tausif1
  • Cresci, Gail A M2
  • 1 Center for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio.
  • 2 Center for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio. Electronic address: [email protected]
Type
Published Article
Journal
Translational research : the journal of laboratory and clinical medicine
Publication Date
Dec 01, 2020
Volume
226
Pages
26–38
Identifiers
DOI: 10.1016/j.trsl.2020.07.004
PMID: 32687975
Source
Medline
Language
English
License
Unknown

Abstract

In the past decade knowledge has expanded regarding the importance of the gut microbiota in maintaining intestinal homeostasis and overall health. During this same time, we have also gained appreciation for the role of the gut-liver axis in the development of liver diseases. Alcohol overconsumption is one of the leading causes of liver failure globally. However, not all people with alcohol use disorder progress to advanced stages of liver disease. With advances in technology to investigate the gut microbiome and metabolome, we are now beginning to delineate alcohol's effects on the gut microbiome in relation to liver disease. This review presents our current understanding on the role of the gut microbiota during alcohol exposure, and various therapeutic attempts that have been made to reprogram the gut microbiota with the goal of alleviating alcoholic-related liver disease. Copyright © 2020 Elsevier Inc. All rights reserved.

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