Microbiota reprogramming for treatment of alcohol-related liver disease.
Center for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio.
Center for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio. Electronic address: [email protected]
- Published Article
Translational research : the journal of laboratory and clinical medicine
- Publication Date
Dec 01, 2020
In the past decade knowledge has expanded regarding the importance of the gut microbiota in maintaining intestinal homeostasis and overall health. During this same time, we have also gained appreciation for the role of the gut-liver axis in the development of liver diseases. Alcohol overconsumption is one of the leading causes of liver failure globally. However, not all people with alcohol use disorder progress to advanced stages of liver disease. With advances in technology to investigate the gut microbiome and metabolome, we are now beginning to delineate alcohol's effects on the gut microbiome in relation to liver disease. This review presents our current understanding on the role of the gut microbiota during alcohol exposure, and various therapeutic attempts that have been made to reprogram the gut microbiota with the goal of alleviating alcoholic-related liver disease. Copyright © 2020 Elsevier Inc. All rights reserved.
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This record was last updated on 02/12/2021 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/32687975