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Microbial O-carbamylation of novobiocin.

Authors
  • Kuo, M S
  • Yurek, D A
  • Chirby, D G
  • Cialdella, J I
  • Marshall, V P
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Oct 01, 1991
Volume
44
Issue
10
Pages
1096–1100
Identifiers
PMID: 1955392
Source
Medline
License
Unknown

Abstract

Novobiocin was inactivated by Streptomyces niveus US 2094 in fermentation. The inactivation product was isolated and characterized by NMR and MS as 2"-O-carbamylnovobiocin. The MICs of novobiocin and 2"-O-carbamylnovobiocin were determined for S. niveus strains.

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