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Microbial and dietary factors modulating intestinal regulatory T cell homeostasis

Authors
  • Kinoshita, Makoto
  • Takeda, Kiyoshi1, 2, 3, 4, 5, 6, 7, 8, 4
  • 1 Laboratory of Immune Regulation
  • 2 Department of Microbiology and Immunology
  • 3 Graduate School of Medicine
  • 4 Osaka University
  • 5 Core Research for Evolutional Science and Technology
  • 6 Japan Science and Technology Agency
  • 7 Laboratory of Mucosal Immunology
  • 8 WPI Immunology Frontier Research Center
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2014
Accepted Date
Mar 10, 2014
Identifiers
DOI: 10.1016/j.febslet.2014.03.018
Source
Elsevier
Keywords
License
Unknown

Abstract

To maintain a quiescent gut microenvironment, proper regulation of immune responses initiated by pro-inflammatory immune subsets is required. Several types of regulatory T cells are reported to exert pivotal roles in achieving this. Among various types of regulatory T cells, the crucial role of Foxp3+ Treg cells has been well documented. Furthermore, accumulating evidence demonstrates that both microbial and dietary factors influence the induction and suppressor functions of intestinal Foxp3+ Treg cells. Foxp3+ Treg cells are a highly activated T cell subset which responds rapidly to environmental and nutritional stimuli. Thus, sufficient nutrient supply is required to fuel the high energetic status of Foxp3+ Treg cells for the regulation of intestinal immunity.

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