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[Is microalbuminuria, an early marker of clinical nephropathy, also a cardiovascular risk factor?].

Authors
  • Raynaud, E
  • Brun, J F
  • Fédou, C
  • Puech-Cathala, A M
  • Pérez-Martin, A
  • Orsetti, A
Type
Published Article
Journal
Annales de biologie clinique
Publication Date
Jan 01, 1998
Volume
56
Issue
6
Pages
671–679
Identifiers
PMID: 9853026
Source
Medline
License
Unknown

Abstract

Microalbuminuria is not only a predictor of diabetic nephropathy in type 1 diabetes, but also a potent marker of cardiovascular risk, especially in type 2 diabetes. Microalbuminuria also predicts cardiovascular morbidity in the general population. We describe semi-quantitative and quantitative methods for determination of low urinary excretion of albumin. Pathogenetic hypotheses common to both renal and endothelial dysfunction are discussed, suggesting that microalbuminuria may be a link between micro- and macroangiopathy. Improved glycemic control and antihypertensive treatment postpone and potentially prevent development of nephropathy in diabetic patients with microalbuminuria. These interventions must be instituted early in the development of diabetic nephropathy. In type 2 diabetes, prospective studies are needed to evaluate the precise impact of such a therapy on the cardiovascular risk.

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