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Mhc-guided processing: binding of large antigen fragments.

Authors
Type
Published Article
Journal
Nat Rev Immunol
Publisher
Nature Publishing Group
Volume
3
Issue
8
Pages
621–621
Source
maverakislab-ucdavis dermatology-ucdavis
License
Unknown

Abstract

Ever since the emergence of models for the processing and presentation of antigenic determinants by MHC class II molecules, the main view has been that proteins are unfolded, enzymatically cleaved into peptide lengths of about 12-25 amino acids and then loaded onto MHC class II molecules. There is, however, an alternative model stating that partially intact unfolding antigens are first bound by MHC class II molecules and then trimmed to fragments of a smaller size while remaining bound to the MHC class II molecule. In this analysis, we make the case that a considerable portion of the elutable peptide cargo belongs to this latter class.

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