Affordable Access

Mg2+ efflux is accomplished by an amiloride-sensitive Na+/Mg2+ antiport.

Authors
  • Günther, T
  • Vormann, J
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Jul 31, 1985
Volume
130
Issue
2
Pages
540–545
Identifiers
PMID: 2992474
Source
Medline
License
Unknown

Abstract

Mg2+ efflux from Mg2+-preloaded chicken erythrocytes is caused by an electroneutral Na+/Mg2+ antiport. It depends specifically on extracellular Na+, according to Michaelis-Menten kinetics (Km = 25 mM), and is reversibly noncompetitively inhibited by amiloride (Ki = 0.59 mM). In contrast to Na+/H+ antiport, Li+, Ca2+ and N-ethylmaleimide do not interfere with Na+/Mg2+ antiport. The Na+/Mg2+ antiport is driven by the intracellular/extracellular Mg2+ gradient.

Report this publication

Statistics

Seen <100 times