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The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease.

Authors
  • Miettinen, Teemu P1
  • Björklund, Mikael1
  • 1 Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee , DD1 5EH Dundee, Scotland, UK.
Type
Published Article
Journal
Molecular & Cellular Oncology
Publisher
Landes Bioscience
Publication Date
May 01, 2016
Volume
3
Issue
3
Identifiers
DOI: 10.1080/23723556.2016.1143546
PMID: 27314093
Source
Medline
Keywords
License
Unknown

Abstract

Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.

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