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Metoclopramide enhances bethanechol-induced pancreatic exocrine secretion of the dog.

Authors
  • Yamagishi, F
  • Haruta, K
  • Homma, N
  • Iwatsuki, K
  • Chiba, S
Type
Published Article
Journal
Clinical and experimental pharmacology & physiology
Publication Date
Jan 01, 1985
Volume
12
Issue
6
Pages
565–571
Identifiers
PMID: 2871953
Source
Medline
License
Unknown

Abstract

The effects of metoclopramide on pancreatic exocrine secretion were investigated in the pentobarbitone-anaesthetized dog. All drugs were injected into the femoral vein. Metoclopramide (10-1000 micrograms/kg) did not change the resting rate of pancreatic secretion. Pancreatic secretion, induced by bethanechol (3 micrograms/kg), was dose-dependently enhanced by simultaneous injections of metoclopramide (10 and 30 micrograms/kg), but the protein and bicarbonate concentrations of the pancreatic juice were not affected. Secretions induced by secretin (0.1 units/kg) and dopamine (3 micrograms/kg) were not modified by metoclopramide at up to 30 micrograms/kg. A larger dose of metoclopramide (1000 micrograms/kg) suppressed dopamine-induced secretion to a lesser extent than the same dose of sulpiride. From these results, it is concluded that metoclopramide enhances secretory responses to cholinergic stimulations by peripherally sensitizing the muscarinic receptor-mediated exocrine process and this drug is a weaker antagonist of the dopamine D2 receptors than sulpiride.

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