Methyltrienolone, a specific ligand for cellular androgen receptors.
- Published Article
- Publication Date
Aug 01, 1975
Methyltrienolone (R 1881), 17beta-hydroxy-17alpha-methyl-estra-4,9,11-trien-3-one, a very active androgen, binds specifically to rat prostate cytosol with a higher affinity than androstanolone. Unlike the physiological hormone, however, it is not bound by human sex steroid plasma binding protein, SBP. This specific ligand is thus a useful tool for the detection of elusive androgen receptors and for their study, for instance, in human tumors where interference from plasma contamination has to be circumvented.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/171806