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Methyltrienolone, a specific ligand for cellular androgen receptors.

Authors
  • Bonne, C
  • Raynaud, J P
Type
Published Article
Journal
Steroids
Publisher
Elsevier
Publication Date
Aug 01, 1975
Volume
26
Issue
2
Pages
227–232
Identifiers
PMID: 171806
Source
Medline
License
Unknown

Abstract

Methyltrienolone (R 1881), 17beta-hydroxy-17alpha-methyl-estra-4,9,11-trien-3-one, a very active androgen, binds specifically to rat prostate cytosol with a higher affinity than androstanolone. Unlike the physiological hormone, however, it is not bound by human sex steroid plasma binding protein, SBP. This specific ligand is thus a useful tool for the detection of elusive androgen receptors and for their study, for instance, in human tumors where interference from plasma contamination has to be circumvented.

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