Affordable Access

Methyloxime-substituted aminopyrrolidine: a new surrogate for 7-basic group of quinolone.

Authors
  • Hong, C Y
  • Kim, Y K
  • Lee, Y H
  • Kwak, J H
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Feb 03, 1998
Volume
8
Issue
3
Pages
221–226
Identifiers
PMID: 9871658
Source
Medline
License
Unknown

Abstract

Novel fluoroquinolones containing oxime functionalized aminopyrrolidines have been synthesized. They were found to possess potent antibacterial activities against both Gram-negative and Gram-positive organisms, including methicillin resistant Staphylococcus aureus (MRSA). Among these compounds, LB20277 (compound 12) showed the most favorable in vivo efficacy and pharmacokinetic profile in animals. Based on these promising results, LB20277 was selected as a candidate for further evaluation.

Report this publication

Statistics

Seen <100 times