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Methylation of miRNA genes and oncogenesis

Authors
  • Loginov, V. I.1, 2
  • Rykov, S. V.3
  • Fridman, M. V.4
  • Braga, E. A.1, 2
  • 1 Institute of General Pathology and Pathophysiology, Moscow, 125315, Russia , Moscow (Russia)
  • 2 Russian Academy of Medical Sciences, Research Center of Medical Genetics, Moscow, 115478, Russia , Moscow (Russia)
  • 3 Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 117545, Russia , Moscow (Russia)
  • 4 Russian Academy of Sciences, Vavilov Institute of General Genetics, Moscow, 117971, Russia , Moscow (Russia)
Type
Published Article
Journal
Biochemistry (Moscow)
Publisher
Pleiades Publishing
Publication Date
Feb 18, 2015
Volume
80
Issue
2
Pages
145–162
Identifiers
DOI: 10.1134/S0006297915020029
Source
Springer Nature
Keywords
License
Yellow

Abstract

Interaction between microRNA (miRNA) and messenger RNA of target genes at the posttranscriptional level provides fine-tuned dynamic regulation of cell signaling pathways. Each miRNA can be involved in regulating hundreds of protein-coding genes, and, conversely, a number of different miRNAs usually target a structural gene. Epigenetic gene inactivation associated with methylation of promoter CpG-islands is common to both protein-coding genes and miRNA genes. Here, data on functions of miRNAs in development of tumor-cell phenotype are reviewed. Genomic organization of promoter CpG-islands of the miRNA genes located in inter- and intragenic areas is discussed. The literature and our own results on frequency of CpG-island methylation in miRNA genes from tumors are summarized, and data regarding a link between such modification and changed activity of miRNA genes and, consequently, protein-coding target genes are presented. Moreover, the impact of miRNA gene methylation on key oncogenetic processes as well as affected signaling pathways is discussed.

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