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Methotrexate for corticosteroid-resistant polymyalgia rheumatica and giant cell arteritis.

Authors
Type
Published Article
Journal
Cleveland Clinic Journal of Medicine
0891-1150
Publisher
Cleveland Clinic Journal of Medicine
Publication Date
Volume
56
Issue
3
Pages
253–257
Identifiers
PMID: 2743546
Source
Medline

Abstract

Three patients (one with polymyalgia rheumatica with jaw claudication and two with biopsy-proven giant cell arteritis) were initially treated using prednisone (40-60 mg daily). The response was good in all three, but each experienced exacerbation of symptoms and elevation of Westergren sedimentation rates (WSR) with dose reduction. The addition of methotrexate (7.5-12.5 mg/wk) resulted in diminished symptoms and lower WSR and proved to be steroid-sparing.

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