Affordable Access

A method for quantifying time dependent changes in MR signal intensity of articular cartilage as a function of tissue deformation in intact joints.

Authors
  • Stammberger, T
  • Herberhold, C
  • Faber, S
  • Englmeier, K H
  • Reiser, M
  • Eckstein, F
Type
Published Article
Journal
Medical Engineering & Physics
Publisher
Elsevier
Publication Date
Dec 01, 1998
Volume
20
Issue
10
Pages
741–749
Identifiers
PMID: 10223643
Source
Medline
License
Unknown

Abstract

A method is proposed to determine accurately the signal intensity changes of the articular cartilage from sectional MR images and its related cartilage deformation under compression in an intact joint. Image processing methods are developed to delineate and register the cartilage boundaries in consecutive MR images in order to track corresponding tissue sectors during the loading experiment. Regions of interest can then be defined and traced during the compression, making a spatial and temporal analysis of signal intensity changes possible. In addition, the cartilage deformation is calculated in the respective tissue sectors and is related to the MR signal changes. Using a fat-suppressed FLASH 3D sequence, the preliminary results showed location-dependent slight changes of the signal intensity varying from individual to individual. The quantitative analysis of the signal intensity changes as a function of cartilage deformation with magnetic resonance imaging (MRI) aims to characterize microstructural properties of the articular cartilage that may lead to a better understanding of degenerative joint disease.

Report this publication

Statistics

Seen <100 times