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Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model.

Authors
  • Johansson, Malin E V1
  • Gustafsson, Jenny K
  • Sjöberg, Karolina E
  • Petersson, Joel
  • Holm, Lena
  • Sjövall, Henrik
  • Hansson, Gunnar C
  • 1 Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Aug 18, 2010
Volume
5
Issue
8
Identifiers
DOI: 10.1371/journal.pone.0012238
PMID: 20805871
Source
Medline
License
Unknown

Abstract

DSS thus causes quick alterations in the inner colon mucus layer that makes it permeable to bacteria. The bacteria that reach the epithelial cells probably trigger an inflammatory reaction. These observations suggest that altered properties or lack of the inner colon mucus layer may be an initial event in the development of colitis.

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