The concentration of plasma vitamin B12 bound to transcobalamin II was measured by two methods: QUSO and Heparin Sepharose (HS). The new HS procedure provided a specific, direct measurement of vitamin B12 bound to both R binder and transcobalamin II in plasma.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/8213000