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Metformin targets c-MYC oncogene to prevent prostate cancer.

Authors
  • Akinyeke, Tunde
  • Matsumura, Satoko
  • Wang, Xinying
  • Wu, Yingjie
  • Schalfer, Eric D
  • Saxena, Anjana
  • Yan, Wenbo
  • Logan, Susan K
  • Li, Xin
Type
Published Article
Journal
Carcinogenesis
Publisher
Oxford University Press
Publication Date
Dec 01, 2013
Volume
34
Issue
12
Pages
2823–2832
Identifiers
DOI: 10.1093/carcin/bgt307
PMID: 24130167
Source
Medline
License
Unknown

Abstract

Metformin, an old antidiabetes drug, may inhibit prostate intraepithelial neoplasia transforming to cancer lesion via reducing c-MYC, an 'old' overexpressed oncogene. This study explores chemopreventive efficacy of metformin in prostate cancer and its link to cMYC in vitro and in vivo.

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