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Metformin targets c-MYC oncogene to prevent prostate cancer.

Authors
Type
Published Article
Journal
Carcinogenesis
1460-2180
Publisher
Oxford University Press
Publication Date
Volume
34
Issue
12
Pages
2823–2832
Identifiers
DOI: 10.1093/carcin/bgt307
PMID: 24130167
Source
Medline
License
Unknown

Abstract

Metformin, an old antidiabetes drug, may inhibit prostate intraepithelial neoplasia transforming to cancer lesion via reducing c-MYC, an 'old' overexpressed oncogene. This study explores chemopreventive efficacy of metformin in prostate cancer and its link to cMYC in vitro and in vivo.

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