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Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Authors
  • Stochino-Loi, Emanuela1
  • Major, Attila L.1, 2
  • Gillon, Tessa E. R.1
  • Ayoubi, Jean-Marc3
  • Feki, Anis1
  • Bouquet de Joliniere, Jean1
  • 1 Department of Obstetrics and Gynecology, Cantonal Hospital, University of Fribourg, Fribourg , (Switzerland)
  • 2 Femina Gynecology Center, Geneva , (Switzerland)
  • 3 Department of Obstetrics and Gynecology, Foch Hospital, University of West Paris, Suresnes , (France)
Type
Published Article
Journal
Frontiers in Medicine
Publisher
Frontiers Media SA
Publication Date
May 11, 2021
Volume
8
Identifiers
DOI: 10.3389/fmed.2021.581311
Source
Frontiers
Keywords
Disciplines
  • Medicine
  • Systematic Review
License
Green

Abstract

Medical treatments for endometriosis aim to control pain symptoms and stop progression of endometriotic lesions. However, their adverse effects and their contraceptive effect in women who desire pregnancy, limit their long terms use. Although there is only one study investigating the effects of metformin on women with endometriosis, metformin seems to have a unique therapeutic potential. It may be a helpful anti-inflammatory and antiproliferative agent in the treatment of endometriosis. As such metformin may be more beneficial thanks to the lack of serious side effects.

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