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Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.

Authors
  • Smolders, Elise J1
  • Colbers, Angela1
  • de Kanter, Clara T M M2
  • Velthoven-Graafland, Kirsten1
  • Wolberink, Leonie T1
  • van Ewijk-Beneken Kolmer, Noor1
  • Drenth, Joost P H3
  • Aarnoutse, Rob E1
  • Tack, Cees J4
  • Burger, David M1
  • 1 Department of Pharmacy and Radboud Institute for Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands. , (Netherlands)
  • 2 Department of Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands. , (Netherlands)
  • 3 Department of Gastroenterology and Hepatology, Radboud university medical center, Nijmegen, the Netherlands. , (Netherlands)
  • 4 Department of Internal Medicine, Radboud university medical center, Nijmegen, the Netherlands. , (Netherlands)
Type
Published Article
Journal
British Journal of Clinical Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2017
Volume
83
Issue
10
Pages
2225–2234
Identifiers
DOI: 10.1111/bcp.13323
PMID: 28474741
Source
Medline
Keywords
License
Unknown

Abstract

Bioequivalence analysis showed that daclatasvir does not influence the pharmacokinetics of metformin in healthy subjects. Pharmacodynamic parameters were also comparable between treatments.

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