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Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex.

Authors
  • Sastry, B S
  • Phillis, J W
Type
Published Article
Journal
Canadian journal of physiology and pharmacology
Publication Date
Feb 01, 1977
Volume
55
Issue
1
Pages
130–133
Identifiers
PMID: 843988
Source
Medline
License
Unknown

Abstract

In rats anaesthetized with a mixture of methoxyflurane, nitrous oxide, and oxygen, the depressant actions on the cerebral cortical neurones of iotophoretically applied 5-hydroxytryptamine (5-HT) but not of noradrenaline, histamine, AMP Ca2+, and gamma-aminobutyric acid were antagonized by metergoline. These observations indicate that metergoline may be a selective 5-HT antagonist in the cerebral cortex.

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