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Metastatic Blue Nevus-Like Melanoma Detected by Liquid-Based Catheterized Urine Cytology.

Authors
  • Kim, Sue Kyung1
  • Yang, Ji Young1
  • Han, Jae Ho2
  • Kwon, Ji Eun2
  • 1 Department of Dermatology, Ajou University School of Medicine, Suwon, Korea. , (North Korea)
  • 2 Department of Pathology, Ajou University School of Medicine, Suwon, Korea. , (North Korea)
Type
Published Article
Journal
Annals of dermatology
Publication Date
Jun 01, 2018
Volume
30
Issue
3
Pages
356–360
Identifiers
DOI: 10.5021/ad.2018.30.3.356
PMID: 29853754
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Primary or metastatic malignant melanoma can mimic benign blue nevus in rare cases, making the diagnosis challenging. Herein, we report an exceptionally rare case of blue nevus-like melanoma and its blue nevus-like metastasis which was detected by catheterized urine cytology. The patient presented with blue-colored papuloplaques on his temple which were diagnosed as blue nevus-like melanoma on punch biopsies. While he was admitted for administration of chemotherapy, hematuria was detected. Catheterized urine cytology revealed singly scattered oval to spindle-shaped pigmented cells with a moderate degree of variation in shape and size. Many of them had small nuclei with indiscernible to inconspicuous nucleoli while only a few cells showed nuclear enlargement and nuclear hyperchromasia, which could be diagnostic pitfalls. Most of the cells on the smear were positive for HMB45 immunostaining, which confirmed the diagnosis of metastatic blue nevus-like melanoma. To the best of our knowledge, the present case is the first report describing cytomorphologic findings of blue nevus-like metastasis of melanoma in the urine specimen.

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