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Meta-omics in Inflammatory Bowel Disease Research: Applications, Challenges, and Guidelines.

Authors
  • Valles-Colomer, Mireia1
  • Darzi, Youssef2
  • Vieira-Silva, Sara1
  • Falony, Gwen1
  • Raes, Jeroen1
  • Joossens, Marie2
  • 1 KU Leuven, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium VIB, Center for the Biology of Disease, Leuven, Belgium. , (Belgium)
  • 2 KU Leuven, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium VIB, Center for the Biology of Disease, Leuven, Belgium Microbiology Unit, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium. , (Belgium)
Type
Published Article
Journal
Journal of Crohn's & colitis
Publication Date
Jun 01, 2016
Volume
10
Issue
6
Pages
735–746
Identifiers
DOI: 10.1093/ecco-jcc/jjw024
PMID: 26802086
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines. © European Crohn’s and Colitis Organistion (ECCO) 2016.

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