AbstractThe Peruvian part of the Andean volcanic belt (AVB) is characterized by significant mineralization. There are explored Au-Ag epithermal, Cu-porphyry, skarn, Fe-oxide (IOCG-type) and polymetallic deposits. The metallogeny of the AVB is determined by the subduction process, i.e., the underthrusting of the Nazca oceanic plate under the margin of the South American continent. The AVB metallogeny is considered on the basis of modern geophysical studies of the lithosphere using data from the GOCE satellite: the gravity field, the Moho surface, and the thermal regime of the upper mantle. The anomaly in the linear distribution of ore objects in the southeast of the studied area of the AVB is apparently due to the influence of the “hot spot” on the composition of magmatic formations and ore-bearing solutions, and IOCG-type objects can be indicators of such environments.