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Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.

Authors
  • Fukuuchi, Tomoko
  • Doh-Ura, Katsumi
  • Yoshihara, Shin'ichi
  • Ohta, Shigeru
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Dec 01, 2006
Volume
16
Issue
23
Pages
5982–5987
Identifiers
PMID: 16987659
Source
Medline
License
Unknown

Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.

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