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Metal complexes as structural templates for targeting proteins

Authors
  • Dörr, Markus
  • Meggers, Eric1, 2
  • 1 Fachbereich Chemie, Philipps-Universität Marburg
  • 2 College of Chemistry and Chemical Engineering, Xiamen University
Type
Published Article
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Volume
19
Pages
76–81
Identifiers
DOI: 10.1016/j.cbpa.2014.01.005
Source
Elsevier
License
Unknown

Abstract

This article reviews recent advances in the design and discovery of inert metal complexes as protein binders. In these metal-based probes or drug candidates, the metal is supposed to exert a purely structural role by organizing the coordinating ligands in the three dimensional space to achieve a shape and functional group complementarity with the targeted protein pockets. Presented examples of sandwich, half-sandwich and octahedral d6-metal complexes reinforce previous perceptions that metal complexes are highly promising scaffolds for the design of small-molecule protein binders and complement the molecular diversity of organic chemistry by opening untapped chemical space.

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